Toxicological Sciences

REVIEW

Get checked abstract Walter C. Prozialeck, Joshua R. Edwards, Daniel W. Nebert, James M. Woods, Aaron Barchowsky, and William D. Atchison

The Vascular System as a Target of Metal Toxicity
ToxSci Advance Access published on October 18, 2007
Toxicol. Sci. 2008 102: 207-218; doi:10.1093/toxsci/kfm263 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Johannes G. Filser, Christoph Hutzler, Florian Rampf, Winfried Kessler, Thomas H. Faller, Edgar Leibold, Christian Pütz, Stefan Halbach, and György A. Csanády

Concentrations of the Propylene Metabolite Propylene Oxide in Blood of Propylene-Exposed Rats and Humans—a Basis for Risk Assessment
ToxSci Advance Access published on January 4, 2008
Toxicol. Sci. 2008 102: 219-231; doi:10.1093/toxsci/kfm311 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Maria Malmlöf, Gerd Pääjärvi, Johan Högberg, and Ulla Stenius

Mdm2 as a Sensitive and Mechanistically Informative Marker for Genotoxicity Induced by Benzo[a]pyrene and Dibenzo[a,l]pyrene
ToxSci Advance Access published on December 20, 2007
Toxicol. Sci. 2008 102: 232-240; doi:10.1093/toxsci/kfm305 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Eva D. McLanahan, Melvin E. Andersen, and Jeffrey W. Fisher

A Biologically Based Dose-Response Model for Dietary Iodide and the Hypothalamic-Pituitary-Thyroid Axis in the Adult Rat: Evaluation of Iodide Deficiency
ToxSci Advance Access published on January 3, 2008
Toxicol. Sci. 2008 102: 241-253; doi:10.1093/toxsci/kfm312 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Shaik Shavali and Donald A. Sens

Synergistic Neurotoxic Effects of Arsenic and Dopamine in Human Dopaminergic Neuroblastoma SH-SY5Y Cells
ToxSci Advance Access published on December 13, 2007
Toxicol. Sci. 2008 102: 254-261; doi:10.1093/toxsci/kfm302 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David C. Volz, Seth W. Kullman, Deanna L. Howarth, Ron C. Hardman, and David E. Hinton

Protective Response of the Ah Receptor to ANIT-Induced Biliary Epithelial Cell Toxicity in See-Through Medaka
ToxSci Advance Access published on January 10, 2008
Toxicol. Sci. 2008 102: 262-277; doi:10.1093/toxsci/kfm308 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Jessica E. S. Bohonowych, Bin Zhao, Alicia Timme-Laragy, Dawoon Jung, Richard T. Di Giulio, and Michael S. Denison

Newspapers and Newspaper Ink Contain Agonists for the Ah Receptor
ToxSci Advance Access published on January 17, 2008
Toxicol. Sci. 2008 102: 278-290; doi:10.1093/toxsci/kfn011 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jay B. Silkworth, Erik A. Carlson, Colin McCulloch, Kati Illouz, Shirlean Goodwin, and Thomas R. Sutter

Toxicogenomic Analysis of Gender, Chemical, and Dose Effects in Livers of TCDD- or Aroclor 1254–Exposed Rats Using a Multifactor Linear Model
ToxSci Advance Access published on January 3, 2008
Toxicol. Sci. 2008 102: 291-309; doi:10.1093/toxsci/kfm313 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Chandra S. Bathula, Scott H. Garrett, Xu Dong Zhou, Mary Ann Sens, Donald A. Sens, and Seema Somji

Cadmium, Vectorial Active Transport, and MT-3–Dependent Regulation of Cadherin Expression in Human Proximal Tubular Cells
ToxSci Advance Access published on January 8, 2008
Toxicol. Sci. 2008 102: 310-318; doi:10.1093/toxsci/kfn004 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Linda R. Klei and Aaron Barchowsky

Positive Signaling Interactions between Arsenic and Ethanol for Angiogenic Gene Induction in Human Microvascular Endothelial Cells
ToxSci Advance Access published on January 8, 2008
Toxicol. Sci. 2008 102: 319-327; doi:10.1093/toxsci/kfn003 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Elisa Ghelfi, Claudia Ramos Rhoden, Gregory A. Wellenius, Joy Lawrence, and Beatriz Gonzalez-Flecha

Cardiac Oxidative Stress and Electrophysiological Changes in Rats Exposed to Concentrated Ambient Particles are Mediated by TRP-Dependent Pulmonary Reflexes
ToxSci Advance Access published on January 9, 2008
Toxicol. Sci. 2008 102: 328-336; doi:10.1093/toxsci/kfn005 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Sudha R. Kondraganti, Weiwu Jiang, Anil K. Jaiswal, and Bhagavatula Moorthy

Persistent Induction of Hepatic and Pulmonary Phase II Enzymes by 3-Methylcholanthrene in Rats
ToxSci Advance Access published on January 17, 2008
Toxicol. Sci. 2008 102: 337-344; doi:10.1093/toxsci/kfn007 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang, and Lijun Wu

Cadmium-Induced Germline Apoptosis in Caenorhabditis elegans: The Roles of HUS1, p53, and MAPK Signaling Pathways
ToxSci Advance Access published on August 28, 2007
Toxicol. Sci. 2008 102: 345-351; doi:10.1093/toxsci/kfm220 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Charlotte E. Hotchkiss, Michelle E. Bishop, Stephen D. Dertinger, William Slikker, Jr, Martha M. Moore, and James T. MacGregor

Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes IV: An Index of Chromosomal Damage in the Rhesus Monkey (Macaca mulatta)
ToxSci Advance Access published on January 21, 2008
Toxicol. Sci. 2008 102: 352-358; doi:10.1093/toxsci/kfn013 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Tina Stevens, Quentin T. Krantz, William P. Linak, Susan Hester, and M. Ian Gilmour

Increased Transcription of Immune and Metabolic Pathways in Naïve and Allergic Mice Exposed to Diesel Exhaust
ToxSci Advance Access published on January 11, 2008
Toxicol. Sci. 2008 102: 359-370; doi:10.1093/toxsci/kfn006 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Kembra L. Howdeshell, Johnathan Furr, Christy R. Lambright, Vickie S. Wilson, Bryce C. Ryan, and L. Earl Gray, Jr

Gestational and Lactational Exposure to Ethinyl Estradiol, but not Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal Sperm Abundance in the Male Long Evans Hooded Rat
ToxSci Advance Access published on December 20, 2007
Toxicol. Sci. 2008 102: 371-382; doi:10.1093/toxsci/kfm306 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Edward L. Carmines and Narayanan Rajendran

Evidence for Carbon Monoxide as the Major Factor Contributing to Lower Fetal Weights in Rats Exposed to Cigarette Smoke
ToxSci Advance Access published on January 17, 2008
Toxicol. Sci. 2008 102: 383-391; doi:10.1093/toxsci/kfn009 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rochelle W. Tyl, Christina B. Myers, Melissa C. Marr, Carol S. Sloan, Nora P. Castillo, M. Michael Veselica, John C. Seely, Stephen S. Dimond, John P. Van Miller, Ronald S. Shiotsuka, Gisela D. Stropp, John M. Waechter, Jr, and Steven G. Hentges

Two-Generation Reproductive Toxicity Evaluation of Dietary 17β-Estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) Mice
ToxSci Advance Access published on January 8, 2008
Toxicol. Sci. 2008 102: 392-412; doi:10.1093/toxsci/kfn002 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jedd M. Hillegass, Caren M. Villano, Keith R. Cooper, and Lori A. White

Glucocorticoids Alter Craniofacial Development and Increase Expression and Activity of Matrix Metalloproteinases in Developing Zebrafish (Danio rerio)
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 102: 413-424; doi:10.1093/toxsci/kfn010 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Bryan Delaney, John Zhang, Gabrielle Carlson, Jean Schmidt, Barb Stagg, Brad Comstock, Amy Babb, Carol Finlay, Robert F. Cressman, Greg Ladics, Amarin Cogburn, Dan Siehl, Luda Bardina, Hugh Sampson, and Youngshin Han

A Gene-Shuffled Glyphosate Acetyltransferase Protein from Bacillus licheniformis (GAT4601) Shows No Evidence of Allergenicity or Toxicity
ToxSci Advance Access published on December 15, 2007
Toxicol. Sci. 2008 102: 425-432; doi:10.1093/toxsci/kfm304 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Grant Bledsoe, Bo Shen, Yu-Yu Yao, Makato Hagiwara, Brandon Mizell, Michael Teuton, Daniel Grass, Lee Chao, and Julie Chao

Role of Tissue Kallikrein in Prevention and Recovery of Gentamicin-Induced Renal Injury
ToxSci Advance Access published on January 27, 2008
Toxicol. Sci. 2008 102: 433-443; doi:10.1093/toxsci/kfn008 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jeppe S. Spicker, Søren Brunak, Klaus S. Frederiksen, and Henrik Toft

Integration of Clinical Chemistry, Expression, and Metabolite Data Leads to Better Toxicological Class Separation
ToxSci Advance Access published on January 4, 2008
Toxicol. Sci. 2008 102: 444-454; doi:10.1093/toxsci/kfn001 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ERRATUM

William J. Fasano, Stephen C. Carpenter, Shawn A. Gannon, Timothy A. Snow, Judith C. Stadler, Gerald L. Kennedy, Robert C. Buck, Stephen H. Korzeniowski, Paul M. Hinderliter, and Raymond A. Kemper

Absorption, Distribution, Metabolism, and Elimination of 8-2 Fluorotelomer Alcohol in the Rat
Toxicol. Sci. 2008 102: 455; doi:10.1093/toxsci/kfn039 [Extract] [Full Text] [PDF] [Request Permissions]  

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