Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Lois D. Lehman-McKeeman

Beam Me Up Scotty: Incorporating Transporters in Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling
ToxSci Advance Access published on April 25, 2008
Toxicol. Sci. 2008 104: 1-3; doi:10.1093/toxsci/kfn075 [Extract] [Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract James J. Pestka, Iwona Yike, Dorr G. Dearborn, Marsha D. W. Ward, and Jack R. Harkema

Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building–Related Illness: New Insights into a Public Health Enigma
ToxSci Advance Access published on November 15, 2007
Toxicol. Sci. 2008 104: 4-26; doi:10.1093/toxsci/kfm284 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Manupat Lohitnavy, Yasong Lu, Ornrat Lohitnavy, Laura S. Chubb, Shuichi Hirono, and Raymond S. H. Yang

A Possible Role of Multidrug Resistance–Associated Protein 2 (Mrp2) in Hepatic Excretion of PCB126, an Environmental Contaminant: PBPK/PD Modeling
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 104: 27-39; doi:10.1093/toxsci/kfn026 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Shu-Ching Chang, Kaberi Das, David J. Ehresman, Mark E. Ellefson, Gregory S. Gorman, Jill A. Hart, Patricia E. Noker, Yu-Mei Tan, Paul H. Lieder, Christopher Lau, Geary W. Olsen, and John L. Butenhoff

Comparative Pharmacokinetics of Perfluorobutyrate in Rats, Mice, Monkeys, and Humans and Relevance to Human Exposure via Drinking Water
ToxSci Advance Access published on March 18, 2008
Toxicol. Sci. 2008 104: 40-53; doi:10.1093/toxsci/kfn057 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Michael L. Gargas, Lisa M. Sweeney, Matthew W. Himmelstein, Lynn H. Pottenger, James S. Bus, and James W. Holder

Physiologically based Pharmacokinetic Modeling of Chloroethane Disposition in Mice, Rats, and Women
ToxSci Advance Access published on April 2, 2008
Toxicol. Sci. 2008 104: 54-66; doi:10.1093/toxsci/kfn064 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Christine Naspinski, Xinsheng Gu, Guo-Dong Zhou, Susanne U. Mertens-Talcott, Kirby C. Donnelly, and Yanan Tian

Pregnane X Receptor Protects HepG2 Cells from BaP-Induced DNA Damage
ToxSci Advance Access published on April 1, 2008
Toxicol. Sci. 2008 104: 67-73; doi:10.1093/toxsci/kfn058 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Abdullah Al Kholaifi, Abeer Amer, Brett Jeffery, Tim J. B. Gray, Ruth A. Roberts, and David R. Bell

Species-Specific Kinetics and Zonation of Hepatic DNA Synthesis Induced by Ligands of PPAR
ToxSci Advance Access published on March 28, 2008
Toxicol. Sci. 2008 104: 74-85; doi:10.1093/toxsci/kfn062 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jennifer M. Phillips and Jay I. Goodman

Identification of Genes that May Play Critical Roles in Phenobarbital (PB)-Induced Liver Tumorigenesis due to Altered DNA Methylation
ToxSci Advance Access published on March 20, 2008
Toxicol. Sci. 2008 104: 86-99; doi:10.1093/toxsci/kfn063 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Olga Beltrán-Ramírez, Leticia Alemán-Lazarini, Martha Salcido-Neyoy, Sergio Hernández-García, Samia Fattel-Fazenda, Evelia Arce-Popoca, Jaime Arellanes-Robledo, Rebeca García-Román, Patricia Vázquez-Vázquez, Adolfo Sierra-Santoyo, and Saúl Villa-Treviño

Evidence that the Anticarcinogenic Effect of Caffeic Acid Phenethyl Ester in the Resistant Hepatocyte Model Involves Modifications of Cytochrome P450
ToxSci Advance Access published on April 7, 2008
Toxicol. Sci. 2008 104: 100-106; doi:10.1093/toxsci/kfn071 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Daniel L. Villeneuve, Lindsey S. Blake, Jeffrey D. Brodin, Jenna E. Cavallin, Elizabeth J. Durhan, Kathleen M. Jensen, Michael D. Kahl, Elizabeth A. Makynen, Dalma Martinovic, Nathaniel D. Mueller, and Gerald T. Ankley

Effects of a 3β-Hydroxysteroid Dehydrogenase Inhibitor, Trilostane, on the Fathead Minnow Reproductive Axis
ToxSci Advance Access published on April 7, 2008
Toxicol. Sci. 2008 104: 113-123; doi:10.1093/toxsci/kfn073 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jerome M. Goldman, Ashley S. Murr, Angela R. Buckalew, and Ralph L. Cooper

Suppression of the Steroid-Primed Luteinizing Hormone Surge in the Female Rat by Sodium Dimethyldithiocarbamate: Relationship to Hypothalamic Catecholamines and GnRH Neuronal Activation
ToxSci Advance Access published on April 7, 2008
Toxicol. Sci. 2008 104: 107-112; doi:10.1093/toxsci/kfn074 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Anna L. Zimmermann, Elizabeth A. King, Emelyne Dengler, Shana R. Scogin, and Wade H. Powell

An Aryl Hydrocarbon Receptor Repressor from Xenopus laevis: Function, Expression, and Role in Dioxin Responsiveness during Frog Development
ToxSci Advance Access published on April 2, 2008
Toxicol. Sci. 2008 104: 124-134; doi:10.1093/toxsci/kfn066 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Patricia T. Caldwell, Patricia A. Thorne, Paula D. Johnson, Scott Boitano, Raymond B. Runyan, and Ornella Selmin

Trichloroethylene Disrupts Cardiac Gene Expression and Calcium Homeostasis in Rat Myocytes
ToxSci Advance Access published on April 14, 2008
Toxicol. Sci. 2008 104: 135-143; doi:10.1093/toxsci/kfn078 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Margie M. Peden-Adams, Jennifer M. Keller, Jackie G. EuDaly, Jennifer Berger, Gary S. Gilkeson, and Deborah E. Keil

Suppression of Humoral Immunity in Mice following Exposure to Perfluorooctane Sulfonate
ToxSci Advance Access published on March 20, 2008
Toxicol. Sci. 2008 104: 144-154; doi:10.1093/toxsci/kfn059 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Dominique Lison, Leen C. J. Thomassen, Virginie Rabolli, Laetitia Gonzalez, Dorota Napierska, Jin Won Seo, Micheline Kirsch-Volders, Peter Hoet, Christine E. A. Kirschhock, and Johan A. Martens

Nominal and Effective Dosimetry of Silica Nanoparticles in Cytotoxicity Assays
ToxSci Advance Access published on April 8, 2008
Toxicol. Sci. 2008 104: 155-162; doi:10.1093/toxsci/kfn072 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Matthew D. Rand, Christin E. Bland, and Jeffrey Bond

Methylmercury Activates Enhancer-of-Split and Bearded Complex Genes Independent of the Notch Receptor
ToxSci Advance Access published on March 25, 2008
Toxicol. Sci. 2008 104: 163-176; doi:10.1093/toxsci/kfn060 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract François Busquet, Roland Nagel, Friedrich von Landenberg, Stefan O. Mueller, Nicole Huebler, and Thomas H. Broschard

Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)
ToxSci Advance Access published on March 28, 2008
Toxicol. Sci. 2008 104: 177-188; doi:10.1093/toxsci/kfn065 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Robert J. Lipinski, Paul R. Hutson, Paul W. Hannam, Robert J. Nydza, Ida M. Washington, Robert W. Moore, Gary G. Girdaukas, Richard E. Peterson, and Wade Bushman

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse
ToxSci Advance Access published on April 14, 2008
Toxicol. Sci. 2008 104: 189-197; doi:10.1093/toxsci/kfn076 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Christopher R. DeSesa, Ryan P. Vaughan, Michael J. Lanosa, Kathryn G. Fontaine, and John B. Morris

Sulfur-Containing Malodorant Vapors Enhance Responsiveness to the Sensory Irritant Capsaicin
ToxSci Advance Access published on March 28, 2008
Toxicol. Sci. 2008 104: 198-209; doi:10.1093/toxsci/kfn061 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Anayi M. Norman, John C. Kissel, Jeffry H. Shirai, Joseph A. Smith, Kelly L. Stumbaugh, and Annette L. Bunge

Effect of PBPK Model Structure on Interpretation of In Vivo Human Aqueous Dermal Exposure Trials
ToxSci Advance Access published on April 1, 2008
Toxicol. Sci. 2008 104: 210-217; doi:10.1093/toxsci/kfn070 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract William O. Osburn, Melinda S. Yates, Patrick D. Dolan, Sining Chen, Karen T. Liby, Michael B. Sporn, Keiko Taguchi, Masayuki Yamamoto, and Thomas W. Kensler

Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice
ToxSci Advance Access published on April 15, 2008
Toxicol. Sci. 2008 104: 218-227; doi:10.1093/toxsci/kfn079 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR

Vincent Kramer, Craig Blewett, and Michael Gersich

Comments on "Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using a Rainbow Trout Vitellogenin Assay"
ToxSci Advance Access published on April 2, 2008
Toxicol. Sci. 2008 104: 228-230; doi:10.1093/toxsci/kfn067 [Extract] [Full Text] [PDF] [Request Permissions]  

Daniel Schlenk

Response to: Comments on "Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using a Rainbow Trout Vitellogenin Assay"
ToxSci Advance Access published on April 2, 2008
Toxicol. Sci. 2008 104: 231-233; doi:10.1093/toxsci/kfn068 [Extract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2008 104: 234; doi:10.1093/toxsci/kfn090 [Extract] [Full Text] [PDF] [Request Permissions]  

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